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Japan approves world’s first regenerative medicines using iPS cells

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2026年2月19日
2 min read
Amchepry approves Cells Cuorips heart failure iPS iPS cells ischemic cardiomyopathy Japan Kyoto University Medicines Osaka Parkinson's disease Racthera regenerative ReHeart Shinya Yamanaka Sumitomo Pharma University of Osaka worlds

Japan approves world’s first regenerative medicines using iPS cells

Japan’s health ministry panel on Thursday approved the commercialisation of two regenerative medicine products prepared from iPS cells, the first of their kind in the world.

The two drugs, ReHeart developed by Cuorips, a start-up originating from the University of Osaka, and Amchepry by Sumitomo Pharma and Racthera, will be used for patients with severe heart failure stemming from ischemic cardiomyopathy and Parkinson’s disease, respectively.

“I am very happy to see the first big step towards its societal implementation, 20 years since it was announced,” said Shinya Yamanaka, director emeritus at Kyoto University’s Centre for iPS Cell Research and Application.

Induced pluripotent stem cells, or iPS, were generated by Yamanaka, who announced the generation of mouse iPS cells in 2006 and human iPS cells in 2007. He won the Nobel Prize in Physiology or Medicine in 2012.

With ReHeart, heart muscle sheets derived from human iPS cells are placed on the surface of the heart, where they promote the formation of new blood vessels underneath and help restore heart function.

Shinya Yamanaka announced the generation of human iPS in 2007. Photo: Wikipedia Commons

Patients with severe heart disease are often given medicine to prevent deterioration and sometimes may have to undergo a heart transplant.

ReHeart, iPS cells, University of Osaka, heart failure, Amchepry, Osaka, Kyoto University, Parkinson's disease, Racthera, Shinya Yamanaka, Japan, Cuorips, ischemic cardiomyopathy, Sumitomo Pharma#Japan #approves #worlds #regenerative #medicines #iPS #cells1771508158